منابع مشابه
Fine-tuning the brain: MicroRNAs.
The brain is of bewildering complexity and numerous genes and signaling molecules have been described that affect the architecture and functioning of specific neuronal circuits. Recent evidence from genome analysis revealed the existence of a large group of novel RNA molecules with unexpected properties. One such group is called microRNAs, which are small 21-23 nucleotides RNA molecules that ar...
متن کاملFine-Tuning Oligodendrocyte Development by microRNAs
Myelination of axons by oligodendrocytes in the central nervous system is essential for normal neuronal functions. The failure of remyelination due to injury or pathological insults results in devastating demyelinating diseases. Oligodendrocytes originate in restricted regions of the embryonic ventral neural tube. After migration to populate all areas of the brain and spinal cord, oligodendrocy...
متن کاملBeta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels
The functions of actin family members during development are poorly understood. To investigate the role of beta-actin in mammalian development, a beta-actin knockout mouse model was used. Homozygous beta-actin knockout mice are lethal at embryonic day (E)10.5. At E10.25 beta-actin knockout embryos are growth retarded and display a pale yolk sac and embryo proper that is suggestive of altered er...
متن کاملMeasures of Fine Tuning
Fine-tuning criteria are frequently used to place upper limits on the masses of superpartners in supersymmetric extensions of the standard model. However, commonly used prescriptions for quantifying naturalness have some important shortcomings. Motivated by this, we propose new criteria for quantifying fine tuning that can be used to place upper limits on superpartner masses with greater fideli...
متن کاملFine tuning of endometrial function by estrogen and progesterone through microRNAs.
Bruce A. Lessey The study by Kuokkanen and coworkers in this issue provides new information on the normal regulation of endometrial function by miRNAs. Minireview. Insulin-like Growth Factors and Fish Reproduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 656 Manfred Reinecke Consideration of the expression and functions of insulin-like growth factors, Igf1 and Igf2,...
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ژورنال
عنوان ژورنال: Cellular and Molecular Biology Letters
سال: 2013
ISSN: 1689-1392
DOI: 10.2478/s11658-012-0038-z